Protein Purification
MilliporeSigma™ Calbiochem™ Splitomicin
A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 μM).
MilliporeSigma™ Calbiochem™ Phloretin
A cell-permeable inhibtor of protein kinase C (IC50 = 20-50 μM).
MilliporeSigma™ Calbiochem™ CD40-TRAF6 Signaling Inhibitor, 6877002
A cell-permeable compound that specifically targets TRAF6 (Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40.
MilliporeSigma™ Calbiochem™ S-Methyl-L-thiocitrulline, Dihydrochloride
A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300nM) compared to the endothelial enzyme (IC50 = 5.4μM).
MilliporeSigma™ Calbiochem™ nor-Binaltorphimine Dihydrochloride
A potent antagonist highly selective for κ opioid receptor with no effect onμ- or &delta- opioid receptors
MilliporeSigma™ Calbiochem™ Dipeptidylpeptidase IV Inhibitor IV, K579
The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1
The Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1, also referenced under CAS 313553-47-8, controls the biological activity of Hec1/Nek2 Mitotic Pathway.
MilliporeSigma™ Calbiochem™ eEF-2 Kinase Inhibitor, NH125
The eEF-2 Kinase Inhibitor, NH125, also referenced under CAS 278603-08-0, controls the biological activity of eEF-2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ CXCR7 Agonist, VUF11207
The CXCR7 Agonist, VUF11207 controls the biological activity of CXCR7. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ NF-κB Activation Inhibitor VII, CID-2858522
The NF-κB Activation Inhibitor VII, CID-2858522 controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ USP1-UAF1 Inhibitor, ML323
A cell-permeable, selective, potent, and reversible inhibitor of USP1-UAF1 deubiquitinase (IC50 = 76 nM in Ub-Rhodamine based assays). Does not disrupt USP1-UAF1 association.
MilliporeSigma™ Calbiochem™ Stearoyl-CoA Desaturase 1 Inhibitor, MF-438
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3nM).
MilliporeSigma™ Calbiochem™ Phosphatase Inhibitor Cocktail Set II, Lyophilized
The Phosphatase Inhibitor Cocktail Set II, Lyophilized controls the activity of Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Calcium Entry Blocker Set, Pyr6 & Pyr10
A set of PYR6, a CRAC Channel Inhibitor III; and PYR10, a TPRC3 Channel Inhibitor III.
MilliporeSigma™ Calbiochem™ RAF Kinase Inhibitor VII
A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out confor